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Bladder wall tension and mechanoreceptor discharge

P Satchell¹, C Vaughan

¹Gordon Craig Laboratory, Department of Surgery, University of Sydney, Australia.

Pflugers Archiv : European Journal of Physiology

|February 1, 1994

Summary

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Bladder mechanoreceptors show altered firing rates with distension speed. Incorporating bladder volume is crucial for understanding continence control systems.

Area of Science:

Urology
Neuroscience
Physiology

Background:

Bladder wall mechanoreceptors are vital for micturition and continence.
Their response to deformation is typically measured by pressure, not tension or volume.

Purpose of the Study:

To investigate the firing patterns of bladder wall mechanoreceptors during varying rates of bladder distension.
To determine if bladder wall tension or volume better explains mechanoreceptor response.

Main Methods:

Recorded firing patterns of 10 single bladder wall mechanoreceptors.
Performed bladder distensions at natural and faster rates.
Analyzed firing rates in relation to pressure, derived tension, and multi-fibre recordings.

Main Results:

Related Experiment Videos

Mechanoreceptor firing rate was higher at any given pressure during slower distension.
This inverse rate dependence diminished when related to bladder wall tension.
The rate dependence was abolished using multi-fibre recordings.

Conclusions:

Bladder wall mechanoreceptor responses are influenced by the rate of distension.
Bladder volume effects should be incorporated into models of continence control.
Tension, rather than pressure, may be a more accurate measure for mechanoreceptor activity.