Effect of Nd:YAG laser on wound contraction and epithelial regeneration in rabbits

This study was undertaken to objectively compare healing rates in wounds produced by the Nd:YAG (Neodymium:Yttrium-Aluminium-Garnet) laser to those caused by steel scalpel, in rabbits. Rates of contraction and epithelialisation in standard wounds were determined by daily measurement of the wound area from the time of wounding until epithelialisation was complete. The wounds were of three types: superficial to the panniculus carnosus, deep to it and ear wounds. Significant delays in both wound contraction (p < 0.0001) and epithelialisation (p < 0.0001) were demonstrated in all Nd:YAG laser wounds. Normal epithelial regenerative capacities were observed. The final appearance of the healed areas was comparable across the laser and scalpel groups.