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Neurotrophic factors and diseases of the nervous system
1Department of Neurosciences, University of California, San Diego, La Jolla 92193.
Abstract:
Neuronal degeneration and death occur in mammals in the course of nervous system development, during senescence, and as a consequence of pathological events throughout life. Neurotrophic factors are natural target-derived molecules that prevent neuronal degeneration and death during development and promote neuronal recovery from injury and age-related atrophy. One neurotrophic factor--nerve growth factor-prevents the death of cells that are a target of varicella-zoster virus: dorsal root sensory neurons. Delivery of neurotrophic factors to dysfunctional neurons may be a useful therapeutic strategy for promoting neuronal recovery in a number of diseases, including varicella-zoster virus infection.
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