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Relationship between respiratory symptoms and cough receptor sensitivity
M F Riordan1, C S Beardsmore, A M Brooke
1Department of Child Health, University of Leicester, Leicester Royal Infirmary.
Archives of Disease in Childhood
|April 1, 1994
Summary
This study found no link between childhood cough history and cough receptor sensitivity in 7-year-olds. Cough threshold, measured by citric acid inhalation, did not correlate with respiratory symptoms or other factors.
Area of Science:
- Pediatric Pulmonology
- Respiratory Medicine
- Clinical Investigation
Background:
- Idiopathic cough is a common issue in children.
- Understanding cough reflex sensitivity is crucial for diagnosing and managing respiratory conditions.
Purpose of the Study:
- To investigate the relationship between preschool respiratory symptoms and current cough receptor sensitivity in children.
- To assess cough threshold using citric acid challenge in different pediatric groups.
Main Methods:
- Forty-six 7-year-old children were divided into healthy, idiopathic cough, and wheezing groups.
- Cough receptor sensitivity was measured by the cough threshold, determined by inhaling increasing concentrations of nebulized citric acid.
Main Results:
- The cough threshold showed no correlation with current respiratory symptoms, bronchial responsiveness, parental smoking, or atopic status.
- A broad range of cough thresholds was observed across all participants.
Conclusions:
- Idiopathic cough in children does not appear to be directly related to cough receptor sensitivity as measured by the citric acid cough threshold.
- Further research is needed to determine if cough threshold accurately reflects overall cough receptor sensitivity.