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[Fungal infection after antibiotic therapy (author's transl)]
Abstract:
The increasing use of antibacterial chemotherapy in the last four decades encourages the commensal colonization of man by candida yeasts. The sites of particular commensal colonization are the oropharyngeal cavity and the intestinal tract. They are the principal reservoirs from which candida infections can settle into other regions and organs. The metastasis of candida yeasts from the commensal reservoir into regions which are free of microorganisms in healthy persons, usually needs a stimulant noxa: an eliciting bacterial infection, a consumptive primary disease, immunosuppressive therapy among other factors. In the event of candida infection being superimposed on a bacterial infection, successful antibacterial chemotherapy may lead to a remission of the mycosis by removal of the primary noxa.
Insights
Antibacterial chemotherapy increases candida yeast colonization in humans, primarily in the gut and mouth. These yeasts can spread to other organs, often triggered by other illnesses or treatments.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Microbiology
Background:
- Widespread use of antibacterial chemotherapy over four decades has influenced human commensal yeast colonization.
- Candida yeasts commonly colonize the oropharyngeal cavity and intestinal tract, serving as primary reservoirs.
Observation:
- Commensal Candida yeasts can metastasize from these reservoirs to normally sterile sites.
- Metastasis typically requires a precipitating factor (stimulant noxa), such as bacterial infections, debilitating diseases, or immunosuppressive therapies.
Findings:
- Superinfection of bacterial infections with Candida can occur.
- Effective antibacterial chemotherapy may resolve the fungal infection (mycosis) by eliminating the primary bacterial trigger.
Implications:
- Understanding yeast reservoirs and metastasis factors is crucial for managing opportunistic fungal infections.
- Targeting bacterial co-infections may offer a therapeutic strategy for certain Candida mycoses.