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Synthesis and antihepatotoxic activity of silybin 11-O-phosphate
1Istituto di Chimica Farmaceutica e Tossicologia, Università di Milano, Italy.
Farmaco (Societa Chimica Italiana : 1989)
|January 1, 1994
Abstract:
Silybin 11-O-phosphate 3 was synthesized by selective phosphorylation of silybin with POCl3. The pharmacological activity of 3 was evaluated in the rat by using the praseodymium poisoning test. Preliminary results showed that the compound possesses antihepatotoxic activity, possibly with lower potency compared to the reference drug silybin hemisuccinate.