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Related Experiment Videos

Utilization of intravenous maltose

U Sprandel, P U Heuckenkamp, N Zöllner

    Nutrition and Metabolism
    |January 1, 1975
    PubMed
    Summary

    Infusing maltose solution in healthy males led to significant maltose excretion in urine. Unexpectedly, this also caused glucosuria despite normal blood glucose levels and increased serum insulin.

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    Area of Science:

    • Metabolism and Nutrition
    • Renal Physiology
    • Carbohydrate Chemistry

    Background:

    • Maltose is a disaccharide commonly used as a carbohydrate source.
    • Understanding the metabolic fate and renal handling of exogenous maltose is crucial for nutritional and clinical applications.

    Purpose of the Study:

    • To investigate the pharmacokinetic and renal excretion profile of maltose following intravenous infusion in healthy human subjects.
    • To assess the impact of maltose infusion on glucose metabolism and insulin response.

    Main Methods:

    • Intravenous infusion of 10% maltose solution at 0.5 g/kg/h for 345 minutes in ten healthy male subjects.
    • Monitoring of blood maltose levels, urinary maltose (maltosuria), and urinary glucose (glucosuria).
    • Measurement of serum insulin levels throughout the infusion period.

    Main Results:

    • Blood maltose levels increased continuously, reaching a plateau after 285 minutes.
    • Significant maltosuria was observed, with an average renal excretion of 30.4% of the administered maltose dose.
    • Concomitant glucosuria occurred, accounting for up to 16% of total carbohydrate excretion, despite normal blood glucose levels.
    • Serum insulin levels demonstrated a rise during the maltose infusion period.

    Conclusions:

    • Intravenous maltose administration leads to substantial renal excretion of maltose in healthy individuals.
    • Maltose infusion can induce glucosuria, even with normal blood glucose levels, suggesting a potential impact on renal glucose transport thresholds.
    • The observed increase in serum insulin indicates a physiological response to maltose administration, possibly involving insulin secretion pathways.

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