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An inflammatory eruption associated with recombinant human IL-6

T E Fleming1, W S Mirando, L F Soohoo

  • 1Department of Dermatology, University Hospitals of Cleveland, Ohio 44106.

The British Journal of Dermatology
|April 1, 1994
PubMed

Interleukin 6 (IL-6) is an endogenous cytokine with multiple biological functions, including amplification of the inflammatory response. Recombinant human IL-6, administered as part of a chemotherapeutic regimen, has recently been shown to cause regression of certain types of malignant tumours. We report a patient who developed a cutaneous eruption consisting of coalescent, erythematous, scaling macules and papules after administration of recombinant human IL-6, given as part of her chemotherapy for ductal carcinoma of the breast.

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