Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Low-level sensory processing in obsessive-compulsive disorder: an evoked potential study

C R Savage1, J B Weilburg, F H Duffy

  • 1Department of Psychiatry, Massachusetts General Hospital, Charlestown 02129.

Biological Psychiatry
|February 15, 1994
PubMed
Summary

Obsessive-compulsive disorder (OCD) is linked to altered auditory processing, specifically faster neural responses in the auditory evoked potential (AEP). Visual evoked potential (VEP) showed no significant differences in OCD patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Randomized, proof-of-concept trial of low dose naltrexone for patients with breakthrough symptoms of major depressive disorder on antidepressants" [J. Affect. Disord. 208 (2017, Jan. 15) 6-14, doi: 10.1016/j.jad.2016.08.029, Epub 2016 Oct. 1].

Journal of affective disorders·2017
Same author

The obese brain as a heritable phenotype: a combined morphometry and twin study.

International journal of obesity (2005)·2016
Same author

COMBINED DELAY AND GRAPH EMBEDDING OF EPILEPTIC DISCHARGES IN EEG REVEALS COMPLEX AND RECURRENT NONLINEAR DYNAMICS.

Proceedings. IEEE International Symposium on Biomedical Imaging·2015
Same author

Prediction of dyslexia in kindergarten boys.

Annals of dyslexia·2013
Same author

Linguistic profiles of dyslexic and good readers.

Annals of dyslexia·2013
Same author

NIDCAP improves brain function and structure in preterm infants with severe intrauterine growth restriction.

Journal of perinatology : official journal of the California Perinatal Association·2012

Area of Science:

  • Neuroscience
  • Psychiatry
  • Sensory Processing

Background:

  • Obsessive-compulsive disorder (OCD) is a complex mental health condition.
  • Understanding the neurobiological underpinnings of OCD is crucial for developing effective treatments.
  • Sensory processing abnormalities may play a role in OCD pathophysiology.

Purpose of the Study:

  • To investigate low-level sensory processing in unmedicated individuals with OCD.
  • To compare auditory evoked potentials (AEP) and visual evoked potentials (VEP) between OCD patients and healthy controls.

Main Methods:

  • Utilized evoked potentials (EPs) including visual evoked potentials (VEP) and auditory evoked potentials (AEP).
  • Recorded EPs in 15 unmedicated subjects with OCD and 30 matched controls.

Related Experiment Videos

  • Stimuli included flash for VEP and binaural click for AEP.

    • Main Results:

    • OCD subjects exhibited significantly shorter latencies for N1 and P2 components of the AEP.
    • No significant differences were observed in the VEP between OCD subjects and controls.
    • Suggests abnormal auditory information processing in OCD.

    Conclusions:

    • Low-level auditory processing is altered in individuals with OCD.
    • Low-level visual processing appears unaffected in OCD based on VEP findings.
    • Results provide insights into neurobiological models of OCD, particularly concerning auditory pathways.