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Malignant lymphoma and dermatitis herpetiformis

S K Bose1, J P Lacour, I Bodokh

  • 1Department of Dermatology, Hôpital Pasteur, University of Nice, France.

Dermatology (Basel, Switzerland)
|January 1, 1994
PubMed
Summary

Dermatitis herpetiformis (DH) is linked to lymphoma, particularly gastro-intestinal non-Hodgkin's lymphoma. Coeliac disease is a common factor, suggesting a gluten-free diet may help prevent lymphoma in DH patients.

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Area of Science:

  • Dermatology
  • Oncology
  • Gastroenterology

Background:

  • Dermatitis herpetiformis (DH) is a chronic autoimmune blistering skin condition.
  • Lymphoma is a cancer of the lymphatic system.
  • The association between DH and lymphoma requires further investigation.

Observation:

  • Two cases of DH associated with distinct lymphoma types are presented: malignant histiocytic lymphoma and a rare Hodgkin's disease phenotype.
  • A literature review identified 32 documented cases of DH with lymphoma.

Findings:

  • The majority of lymphomas (78.1%) associated with DH originate in the gastro-intestinal tract.
  • Nearly all reported cases of DH with lymphoma are linked to coeliac disease.

Implications:

  • This association highlights the importance of screening for gastro-intestinal malignancies in DH patients.
  • The findings support the potential role of a gluten-free diet in preventing lymphoma development in individuals with DH and coeliac disease.

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