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Marchiafava-Bignami disease. Premortem diagnosis of an acute case utilizing magnetic resonance imaging
J Marjama1, M T Yoshino, C Reese
1Department of Neurology, University of Arizona Health Sciences Center, Tucson 85724.
Abstract:
Marchiafava-Bignami disease is a rare demyelinating disease involving the corpus callosum and other central white matter tracts. In the patient described here, the disease produced extensive demyelination of the corpus callosum and deep cerebral white matter. This widespread demyelination, confirmed pathologically, was associated with a fulminant fatal course. The magnetic resonance imaging appearance is quite suggestive of Marchiafava-Bignami disease and plays an important role in the premortem diagnosis.
Insights
Marchiafava-Bignami disease, a rare corpus callosum demyelination, can lead to rapid, fatal outcomes. Magnetic resonance imaging is crucial for its premortem diagnosis.
Area of Science:
- Neurology
- Neuroscience
- Pathology
Background:
- Marchiafava-Bignami disease (MBD) is a rare neurological disorder.
- It primarily affects the corpus callosum and central white matter.
Observation:
- A case of MBD presented with extensive demyelination.
- The demyelination involved the corpus callosum and deep cerebral white matter.
Findings:
- Pathological confirmation revealed widespread demyelination.
- The disease followed a fulminant and fatal clinical course.
Implications:
- Magnetic resonance imaging (MRI) findings are highly suggestive of MBD.
- MRI plays a critical role in the premortem diagnosis of this rare condition.
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