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Dose-dependency of hepatocellular necrosis in a canine model of chemoembolization
Purpose:
The degree of local tissue toxicity from hepatic arterial chemoembolization relative to the dose of anticancer drugs was evaluated in 13 dogs.
Materials And Methods:
Animals were divided into four groups. Group 1 was the control group in which embolization was performed with gelatin sponge particles only (n = 4); group 2 animals underwent embolization with 0.4 mg/kg of Adriamycin (ADR) and 0.2 mg/kg of mitomycin C (MMC) (n = 4); group 3, with 0.8 mg/kg of ADR and 0.4 mg/kg of MMC (n = 2); and group 4, with 1.6 mg/kg of ADR and 0.8 mg/kg of MMC (n = 3).
Results:
Animals were killed 1 week after embolization, and histopathologic evaluation was performed. The average percentage liver necrosis in the embolized lobe was 0% in group 1, 1% in group 2, 85% in group 3, and 92% in group 4.
Conclusion:
Hepatic arterial chemoembolization with high doses of anticancer drugs causes severe liver damage, but 0.4 mg/kg of ADR and 0.2 mg/kg of MMC is relatively safe, causing only minimal changes in this canine model.