Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sotalol in angina pectoris. A double-blind study

R Slome

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |March 20, 1976
    PubMed
    Summary

    Sotalol, a beta-adrenergic blocking drug, effectively reduced angina pectoris attacks and improved exercise tolerance in patients with stable angina. A moderate daily dose proved sufficient for most patients with minimal side-effects.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Levodopa in parkinsonism.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·1977
    Same author

    Diffuse arteritis, long-term immunosuppression and malignancy.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·1976
    Same author

    In memoriam: Joseph Gardiner.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·1975
    Same author

    The use of intravenous verapamil in cardiac arrhythmias.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·1973
    Same author

    Withdrawal of propranolol and myocardial infarction.

    Lancet (London, England)·1973
    Same author

    The syndrome of recurrent idiopathic pericarditis.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·1968

    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Stable angina pectoris presents a significant clinical challenge.
    • Beta-adrenergic blockers are a cornerstone in managing ischemic heart conditions.

    Purpose of the Study:

    • To evaluate the efficacy of sotalol in reducing angina frequency and improving exercise tolerance.
    • To assess the optimal dosage and side-effect profile of sotalol in angina patients.

    Main Methods:

    • A double-blind, cross-over study design was employed.
    • Thirty patients with stable angina pectoris participated in the trial.
    • Sotalol's effects on angina attacks, medication use, and exercise capacity were measured.

    Main Results:

    • Sotalol significantly decreased the frequency of angina attacks and glyceryl trinitrate consumption.
    • Patients demonstrated improved exercise tolerance and enhanced electrocardiographic responses.
    • A daily dose of 320 mg sotalol was effective in 80% of participants.

    Conclusions:

    • Sotalol is a safe and effective treatment for stable angina pectoris.
    • Moderate doses of sotalol can significantly improve clinical outcomes and exercise capacity.
    • The drug exhibits a favorable side-effect profile, making it a viable therapeutic option.

    Related Experiment Videos