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Related Experiment Videos

Contact dermatitis from the old formula E45 cream

T L Batten1, R A Wakeel, W S Douglas

  • 1Department of Dermatology, Aberdeen Roayl Infirmary, Aberdeen Royal Hospitals Trust, Foresterhill, UK.

Contact Dermatitis
|March 1, 1994
PubMed
Summary

High rates of adverse reactions to E45 cream were observed. Triethanolamine in the cream was identified as a likely cause, prompting its removal from the formulation.

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Area of Science:

  • Dermatology
  • Contact Dermatitis
  • Cosmetic Science

Background:

  • E45 cream is a widely used emollient.
  • A high incidence of positive patch test reactions to E45 cream has been noted.
  • Previous studies have not fully elucidated the cause of these reactions.

Purpose of the Study:

  • To investigate the cause of adverse reactions associated with E45 cream.
  • To identify specific ingredients responsible for allergic or irritant contact dermatitis.
  • To evaluate the role of triethanolamine stearate formation in E45 cream-induced reactions.

Main Methods:

  • Patch testing of patients with suspected E45 cream allergy.
  • Testing of individual E45 cream ingredients.
  • Conductivity studies to assess triethanolamine stearate formation.

Related Experiment Videos

  • Irritancy testing of triethanolamine stearate in patients and controls.

    • Main Results:

    • A significant number of patients showed positive patch test reactions to E45 cream.
    • Triethanolamine was the most frequent cause of ingredient allergy.
    • Triethanolamine stearate formation was confirmed and demonstrated to be irritant.
    • Lanolin allergy was rare.

    Conclusions:

    • Triethanolamine is a significant cause of allergic and irritant reactions to E45 cream.
    • The formation of irritant triethanolamine stearate contributes to adverse effects.
    • The removal of triethanolamine from E45 cream formulation is a necessary change.