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Related Experiment Videos

Temporary ectropion due to topical fluorouracil

D Hecker1, S M Hacker, F A Ramos-Caro

  • 1University of Florida College of Medicine, Gainesville 32610-0277.

Cutis
|March 1, 1994
PubMed
Summary

Topical 5-fluorouracil cream, a treatment for actinic keratoses, can cause temporary ectropion (eyelid turning). This rare side effect resolved after discontinuing the medication.

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Area of Science:

  • Dermatology
  • Ophthalmology

Background:

  • Actinic keratoses (AKs) are common pre-malignant skin lesions.
  • Topical 5-fluorouracil (5-FU) is a standard treatment for AKs.

Observation:

  • A patient developed bilateral ectropion, an outward turning of the eyelids, within two weeks of initiating topical 5-FU therapy for AKs.

Findings:

  • The observed ectropion was transient, completely resolving upon cessation of the 5-FU treatment.
  • This represents the first documented instance of ectropion as a side effect of topical 5-FU.

Implications:

  • Clinicians should be aware of this potential ocular side effect when prescribing topical 5-FU.
  • Monitoring for ectropion may be warranted in patients undergoing 5-FU treatment, particularly those with facial lesions near the eyes.

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