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Globular hyaline microthrombi--their nature and morphogenesis

U Bleyl, J A Rossner

    Virchows Archiv. A, Pathological Anatomy and Histology
    |May 3, 1976
    PubMed
    Summary

    Globular hyaline microthrombi (GHM) exhibit a unique ultrastructure with fibrin-characteristic periodicity. Secondary fibrinolysis, or endolysis, is indicated by the loss of this periodicity and fibrillary structure in GHM.

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    Area of Science:

    • Pathology
    • Biophysics
    • Medical Ultrastructure

    Background:

    • Globular hyaline microthrombi (GHM) are observed in various shock states.
    • Understanding the ultrastructure of GHM is crucial for diagnosing and understanding shock-related pathologies.

    Purpose of the Study:

    • To describe the detailed ultrastructure of globular hyaline microthrombi (GHM).
    • To investigate the relationship between GHM ultrastructure and secondary fibrinolysis (endolysis).
    • To discuss the morphogenesis of GHM in different etiologies of shock.

    Main Methods:

    • Transmission electron microscopy was used to examine the ultrastructure of GHM.
    • Analysis focused on fibrillar structures, periodicity, and spatial arrangement within GHM.
    • Comparison of GHM ultrastructure across different shock states.

    Main Results:

    • GHM exhibit a spherical space lattice with interconnected fiber bundles and a 23 nm axial periodicity characteristic of fibrin.
    • A surrounding corona of radially spreading fibers is also observed.
    • Some GHM lack axial periodicity and fibrillary structure, presenting as amorphous precipitates, indicative of endolysis.

    Conclusions:

    • The morphological changes in GHM, particularly the loss of axial periodicity and fibrillary structure, represent endolysis.
    • GHM ultrastructure provides insights into the dynamic processes occurring during shock.
    • Further research into GHM morphogenesis can aid in understanding shock pathophysiology.

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