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Conserved linkage of early growth response 4, annexin 4, and transforming growth factor alpha on mouse chromosome 6
L L Barrow1, K Simin, J M Jones
1Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109-0618.
Abstract:
The mouse genes encoding early growth response 4 (Egr4), annexin IV (Anx4), and transforming growth factor alpha (Tgfa) have been mapped to a linkage group on mouse chromosome 6 that is conserved on human chromosome 2p11-p13. The genes are closely linked, with 0/215 recombinants between Anx4 and Tgfa and 1/215 recombinants between these genes and Egr4. The genes are located approximately 2 cM distal to mnd2, a mouse mutation causing neuromuscular disease. The results demonstrate that mnd2 is located at an internal position within this conserved linkage group.
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