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Published on: January 4, 2018
Localization of glucose-dependent insulinotropic polypeptide (GIP) to a gene cluster on chromosome 17q
T B Lewis1, M Saenz, P O'Connell
1Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284.
Abstract:
Glucose-dependent insulinotropic polypeptide (GIP) has been regionally localized to a gene cluster on human chromosome 17q. Genetic mapping through CEPH reference families demonstrated that GIP was tightly linked to NME1 and PPY and fully linked to HOXB6 and NGFR. High-resolution radiation hybrid mapping resolved the gene order as cen-PPY-HOXB6-NGFR-GIP-NME1-tel. GIP maps distal to NGFR with an estimated distance of 250 kb.
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