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Updated: Aug 6, 2026
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Antipsoriatic effect of fumaric acid derivatives. Results of a multicenter double-blind study in 100 patients
P J Altmeyer1, U Matthes, F Pawlak
1Dermatological Clinic, University of Bochum, Germany.
Background:
Psoriasis vulgaris may benefit from treatment with fumaric acid and/or its derivatives; however, because different preparations have been used, results have been contradictory and difficult to interpret.
Objective:
The purpose of this clinical trial was to evaluate the therapeutic value of fumaric acid derivatives.
Methods:
A randomized double-blind study was carried out in patients with psoriasis, comparing a well-characterized formulation of fumaric acid derivatives with placebo.
Results:
The results indicated statistically significant superiority of the fumaric acid derivatives over placebo. Adverse events (flush, gastrointestinal disturbances) were initially relatively frequent, but decreased thereafter.
Conclusion:
Fumaric acid derivatives were found to be effective and safe in the treatment of psoriasis.
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