Sclerotic fibroma: a fossil no longer
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Updated: Sep 25, 2026
Murine Dermal Fibroblast Isolation by FACS
Published on: January 7, 2016
1Department of Pathology, University of California Medical Center, San Francisco 94143-0506.
Abstract:
We report on a patient with a sclerotic fibroma that recurred 30 months after initial removal. The histologic features were characteristic, and immunoperoxidase stains using primary antibodies directed against cell proliferation markers were positive in a significant proportion of the neoplastic nuclei. A review of the literature identified one other sclerotic fibroma that persisted. These clinical and light microscopic features support the interpretation that sclerotic fibroma is a proliferating neoplasm with an unusual histologic pattern, rather than the end-stage of a process that was formerly more cellular. We advocate use of sclerotic fibroma as the preferred diagnostic term.
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