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Related Experiment Videos

Histopathologic changes in the aging human cricoarytenoid joint

R R Casiano1, P J Ruiz, W Goldstein

  • 1Department of Otolaryngology, University of Miami School of Medicine, Fla.

The Laryngoscope
|May 1, 1994
PubMed
Summary

Aging voice changes are not primarily caused by the cricoarytenoid joint. Histological analysis revealed progressive ossification and muscle atrophy, suggesting other laryngeal factors influence senescent vocal quality.

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Area of Science:

  • Otolaryngology
  • Gerontology
  • Anatomic Pathology

Background:

  • Voice changes are common in aging populations.
  • The cricoarytenoid joint's role in age-related voice alterations is hypothesized.
  • Histological changes in the joint may affect laryngeal structure and function.

Purpose of the Study:

  • To investigate age-related histological changes in the human cricoarytenoid joint.
  • To determine if cricoarytenoid joint alterations contribute to senescent vocal quality.

Main Methods:

  • Histopathological examination of seven human larynges (ages 29-69).
  • Evaluation of synovium, joint space, periarticular muscle, and epithelium.
  • Assessment of ossification, elastin, collagen, inflammation, edema, and vascularity.

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Main Results:

  • No significant age-related changes in synovium or joint space.
  • No differences in elastin or collagen formation with age.
  • Progressive ossification of cricoid and arytenoid cartilages observed.
  • Periarticular muscular atrophy and fibrosis increased with age.

Conclusions:

  • Age-related voice changes may not stem from the cricoarytenoid joint itself.
  • Progressive ossification and muscular changes in surrounding laryngeal structures are noted.
  • Other laryngeal factors likely play a more significant role in senescent vocal quality.