Related Experiment Videos
Transfer of elevated anti-S-100 autoimmunity from mother to offspring in rats
1Chernobyl-TEST Center, Moscow, Russia.
Pregnant Wistar female rats were injected with polyclonal rabbit antibodies (AB) to S-100 brain protein. Control groups received equivalent amount of AB to bovine serum albumin or non-immune rabbit's IgG. An increased level of anti-S100 immunoreactivity was detected by ELISA or its enhanced variant ASPAG (from Amplified Solid Phase Attached Antigen-Antibody Grid formation) in the serum of 1 month old offsprings of group treated with AB to S-100. Obtained data indicate the possibility of inborn epigenetical "imprinting" of specific autoimmune reactions which may be important for the development of certain forms of nervous system diseases.
Pregnant Wistar female rats were injected with polyclonal rabbit antibodies (AB) to S-100 brain protein. Control groups received equivalent amount of AB to bovine serum albumin or non-immune rabbit's IgG. An increased level of anti-S100 immunoreactivity was detected by ELISA or its enhanced variant ASPAG (from Amplified Solid Phase Attached Antigen-Antibody Grid formation) in the serum of 1 month old offsprings of group treated with AB to S-100. Obtained data indicate the possibility of inborn epigenetical "imprinting" of specific autoimmune reactions which may be important for the development of certain forms of nervous system diseases.