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Related Experiment Videos

Ultraviolet solid-state laser (213-nm) photorefractive keratectomy. In vivo study

Q Ren1, G Simon, J M Legeais

  • 1Department of Ophthalmology, University of California at Irvine 92715.

Ophthalmology
|May 1, 1994
PubMed
Summary

The 213-nm solid-state laser shows promise for photorefractive keratectomy (PRK), with rabbit corneas demonstrating effective healing and comparable histopathology to the 193-nm excimer laser. Further human trials are needed to confirm its efficacy in refractive surgery.

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Area of Science:

  • Ophthalmology
  • Laser Surgery
  • Biomedical Engineering

Background:

  • The 213-nm solid-state laser is explored as an alternative to the 193-nm excimer laser for photorefractive keratectomy (PRK).
  • This study investigates the clinical and histopathological outcomes of PRK using the 213-nm laser in rabbit corneas.

Purpose of the Study:

  • To evaluate the clinical course and histopathologic changes in rabbit corneas following PRK with a 213-nm solid-state laser.
  • To compare the findings with established results from 193-nm excimer laser PRK.

Main Methods:

  • Seven rabbit corneas underwent 5-mm optical zone ablations using a 213-nm neodymium:YAG frequency-quintupled laser with a scanning delivery system.
  • Radiant exposure was 250 mJ/cm², targeting 4.0 diopters (approx. 40 microns ablation depth).

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  • Clinical assessments of epithelial healing and stromal haze were performed over 3 months, with corneal tissues analyzed via light and transmission electron microscopy at various intervals.

    • Main Results:

    • Complete corneal re-epithelialization occurred within 10 days.
    • Stromal haze peaked at 1 month and gradually resolved, with residual subepithelial haze at 3 months.
    • Histopathology confirmed normal epithelial healing, intact basement membrane, and abundant hemidesmosomes; increased anterior stromal fibroblasts were noted transiently, along with a mild, temporary cellular reaction in the stroma and endothelium.

    Conclusions:

    • PRK with the 213-nm ultraviolet solid-state laser and scanning delivery system yields clinical and histopathologic results similar to 193-nm excimer PRK in rabbits.
    • The procedure is deemed clinically viable for refractive surgery.
    • Further human clinical trials are recommended to ascertain its efficacy.