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Updated: Aug 12, 2026
05:49
Modeling the Effects of Hemodynamic Stress on Circulating Tumor Cells using a Syringe and Needle
Published on: April 27, 2021
[Hemorheologic changes in cancer patients]
1Budai Honvédkórház, Haemorheologiai Laboratórium.
Orvosi Hetilap
|May 1, 1994
Summary
Malignant tumors can alter blood flow properties. Patient plasma significantly reduced red blood cell flexibility, impacting blood rheology in cancer patients.
Area of Science:
- Hematology
- Oncology
- Biophysics
Context:
- Investigated hemorheological alterations in patients with malignant tumors.
- Focused on micro- and macrorheological parameters of blood and plasma.
- Included analysis of whole blood viscosity, yield shear stress, and plasma viscosity.
Purpose:
- To assess the impact of malignant tumors on blood rheology.
- To determine the effect of patient plasma on erythrocyte deformability.
- To identify specific rheological abnormalities associated with cancer.
Summary:
- Whole blood viscosity was largely normal, but yield shear stress and plasma viscosity were frequently abnormal.
- Patient plasma significantly impaired erythrocyte deformability, leading to elevated red cell transit time.
- Seven patients exhibited normal erythrocyte deformability in buffer but abnormal function in their own plasma.
Impact:
- Highlights the role of plasma in cancer-associated hemorheological changes.
- Suggests impaired erythrocyte deformability as a potential consequence of the tumor microenvironment.
- Provides insights into the complex rheological disturbances in malignancy.
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