[Autoantibodies or immune defense against cholesterol?]

Serological study was made on the lues aspecific positive sera (BAP); The serum reactivity was demonstrated by Kolmer and rapid plasma reagin (RPR) tests. The specificity was verified by treponema immobilization est (TPIT), fluorescent treponemal antibody (FTA-ABS) and treponema haemagglutination (TPHA) tests. The BAP sera were studied by enzyme labelled immunoassay (ELISA) with the isolated antigen components of Kolmer and RPR tests. The previously supposed "cardio-BAP" appeared only about 50 per cent of the sera. Anti-cholesterol antibody was demonstrated in 38 sera of 112 (33.9%) and only one of 50 negative control sera (2%). To the author's knowledge anti-cholesterol antibodies have never been demonstrated before. The authors suppose it is an autoantibody and their new result will give new possibilities to understand and explain the role of cholesterol in the so called "cholesterol diseases". Additional research have to be made to specify the pathological importance and role in the disorders.