[Effect of cigarette smoking on carbohydrate metabolism of healthy subjects]

Serum levels of triglycerides (TG), cholesterol (CH), total lipids (LP), beta-lipoproteids (B-LP), basal glucose and immunoreactive insulin were assessed in 23 healthy subjects (12 non-smokers and 11 smokers). Influence of smoking cigarettes on level of glycemia and insulin secretion in basal conditions and 30, 60, 90 and 120 minutes after load of 75 g glucose. Concentration of glucose was measured by an enzymatic method and level of IRI by radioimmunoassay. Smokers differed from non-smokers in significantly higher diastolic blood pressure and non-significantly higher concentration of TG, CH, LP, B-LP. No statistically significant difference in basal glucose level and profile of glycemia were found between both groups. Significantly higher basal level of insulinemia and increased secretion of insulin after an oral glucose tolerance test were observed in comparison with non-smokers.

1) The significant higher level of serum basal IRI was found in smokers when compared to non-smokers. 2) Results suggest non-effective hyperinsulinemia in people smoking cigarettes.