[Body structure and ABO and Rh blood groups in patients with advanced coronary heart disease after aorto-coronary by-pass surgery]
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Z Slipko1, B Latuchowska, E Wojtkowska
1Kliniki Rehabilitacji Kardiologicznej Instytutu Kardiologii, Warszawie.
Insights
This study found that individuals with advanced coronary artery disease undergoing bypass surgery are more likely to have blood group AB and lack the rhesus factor. Anthropometric traits showed no significant differences compared to controls.
Area of Science:
- Clinical Medicine
- Cardiology
- Genetics
Context:
- Coronary heart disease (CHD) is a leading cause of mortality worldwide.
- Understanding the genetic and anthropometric factors associated with CHD severity and treatment outcomes is crucial for personalized medicine.
- Previous research has explored various risk factors, but the specific associations with blood groups and anthropometry in patients undergoing aorto-coronary bypass surgery require further investigation.
Purpose:
- To investigate the relationship between anthropometric traits, ABO blood groups, and rhesus blood groups in male patients with coronary heart disease.
- To determine if specific blood groups or anthropometric characteristics are associated with the need for aorto-coronary bypass surgery due to advanced arteriosclerosis.
Summary:
- A clinical analysis of 200 male patients (aged 31-68) with coronary heart disease was conducted, comparing their anthropometric data and blood groups to control populations.
- Patients undergoing aorto-coronary bypass surgery for advanced coronary artery disease showed a significantly higher prevalence of blood group AB (p < 0.01) and a deficiency in blood group O (p < 0.05).
- A significantly higher occurrence of rhesus blood group absence was observed in patients who had undergone bypass surgery (p < 0.01). No significant differences in anthropometric traits were found between surgical patients and controls.
Impact:
- The findings suggest a potential link between specific ABO and rhesus blood groups and the severity of coronary artery disease requiring surgical intervention.
- This research could contribute to risk stratification and inform future studies on the genetic predispositions to severe coronary artery disease.
- Highlights the importance of considering blood group antigens in the context of cardiovascular health and surgical outcomes.
Abstract:
A clinical analysis of the anthropometric traits related to body structure, ABO and rhesus blood groups was performed in 200 male individuals coming mainly from Warsaw and its territorial district. All patients were aged from thirty-one to sixty-eight years (X = 42.3) and total duration of coronary heart disease was from 1 to 12 years. The number of 54 patients (21%) was subjected to surgery because of coronary insufficiency, but without myocardial infarction (M.I.). One or three single cases of M.I. were reported in the remaining number of 146 patients (73%). A degree of extension of arteriosclerotic lesions either in two or three coronary arteries was larger determined upon coronarography. The control group for blood--groups in 200 patients was made of 11,820 healthy male--blood from District Blood Donor Station in Warsaw, but for the anthropometric tracts (height, body weight and Rohrer's index) the control group was made of 283 men aged 35-80 years (average 43.2) coming mainly from Warsaw and its district. Patients after aorto-coronary by-pas surgery with highly advanced arteriosclerosis of the coronary arteries featured indicated significantly higher number of cases with group AB (p < 0.01) due to deficiency in group O (p < 0.05). It has also been found that the occurrence of rhesus blood group lack in patients having undergone by-pass surgery is significantly common (p < 0.01). No significant difference in anthropological traits between the patients after aorto-coronary by-pass surgery and the control group from the same geographical region was reported.(ABSTRACT TRUNCATED AT 250 WORDS)