Related Experiment Videos
Corticotropin releasing hormone is involved in exercise-induced elevation in core temperature
1Division of Kinesiology, University of Michigan, Ann Arbor.
Psychoneuroendocrinology
|January 1, 1994
Summary
Corticotropin-releasing factor (CRF) plays a role in raising body temperature during exercise in female rats. Blocking CRF reduced exercise-induced temperature increases without affecting activity levels.
Area of Science:
- Neuroendocrinology
- Exercise Physiology
Background:
- Exercise increases core body temperature.
- The role of corticotropin-releasing factor (CRF) in this thermogenic response is not fully understood.
Purpose of the Study:
- To investigate the involvement of CRF in exercise-induced hyperthermia in female rats.
Main Methods:
- Rats were administered CRF antibody or vehicle intracerebroventricularly (ICV).
- Locomotor activity and body temperature were monitored.
- Rats had access to exercise wheels for 6 weeks prior to injection.
Main Results:
- CRF antibody injection did not alter body temperature or activity on the day of injection.
- Exercising rats receiving CRF antibody showed significantly attenuated daytime core temperature one day post-injection compared to controls.
- This temperature reduction was independent of changes in locomotor activity.
Conclusions:
- CRF is implicated in the exercise-induced elevation of daytime core body temperature in female rats.
- The findings suggest a potential role for cytokines, such as IL-1 beta, in mediating this CRF-dependent thermogenic response during exercise.