Related Experiment Video

Updated: Aug 20, 2026

Surgical Models of Gastroesophageal Reflux with Mice
05:19

Surgical Models of Gastroesophageal Reflux with Mice

Published on: August 25, 2015

[gastroesophageal reflux in children, a curiosity or a disease?]

M Scaillon1, S Candranel

  • 1Clinique de Gastro-Entérologie-Hépathologie, Hôpital des Enfants Reine Fabiola, Bruxelles.

Revue Medicale De Bruxelles
|January 1, 1994
PubMed

Insights

New pediatric techniques improve understanding of infant gastro-oesophageal reflux (GOR). While often temporary, persistent GOR can cause chronic issues and, rarely, severe infant health problems.

Area of Science:

  • Pediatric Gastroenterology
  • Infant Health
  • Reflux Disease Mechanisms

Context:

  • Advancements in diagnostic techniques and miniaturization for pediatric applications.
  • Understanding the pathophysiology of gastro-oesophageal reflux (GOR) in infants and children.
  • Importance of accurate GOR detection for non-digestive manifestations.

Purpose:

  • To elucidate the pathogenic mechanisms of infantile and childhood gastro-oesophageal reflux (GOR).
  • To highlight the significance of reliable GOR detection in managing non-digestive symptoms.
  • To differentiate between transient and persistent GOR in pediatric populations.

Summary:

  • Miniaturized techniques enhance the understanding of gastro-oesophageal reflux (GOR) in pediatric patients.
  • GOR is typically transient in infants but can persist beyond 18-24 months, leading to chronic complaints.
  • Persistent GOR, though rare, can result in severe morbidity and mortality in early infancy.

Impact:

  • Improved diagnostic capabilities for pediatric gastro-oesophageal reflux (GOR).
  • Better identification and management of chronic GOR complications in children.
  • Potential reduction in severe GOR-related morbidity and mortality in neonates and infants.

More Related Videos

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring06:46

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Published on: December 14, 2020

Construction of a Wireless-Enabled Endoscopically Implantable Sensor for pH Monitoring with Zero-Bias Schottky Diode-based Receiver08:25

Construction of a Wireless-Enabled Endoscopically Implantable Sensor for pH Monitoring with Zero-Bias Schottky Diode-based Receiver

Published on: August 27, 2021

Related Concept Videos

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology01:29

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology

Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Esophageal Achalasia01:27

Esophageal Achalasia

Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide (VIP)...
Gastroesophageal Reflux Disease01:25

Gastroesophageal Reflux Disease

Gastroesophageal reflux disease (GERD) is the backward flow of stomach contents (acid, pepsin, or bile) into the esophagus, causing mucosal inflammation known as esophagitis. It results from failure of antireflux mechanisms, mainly the lower esophageal sphincter (LES), influenced by mechanical and physiological factors.Etiology and Risk FactorsGERD develops when LES function is weakened or when intra-abdominal pressure increases. Risk factors include aging, obesity, and sliding hiatal hernia,...