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True histiocytic lymphoma with multiple skin nodules
1Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Ultrastructural Pathology
|January 1, 1994
Summary
A rare case of true histiocytic lymphoma presented with fluctuating skin nodules. Electron microscopy was crucial for diagnosing this histiocyte proliferation disorder.
Area of Science:
- Oncology
- Dermatology
- Hematology
Background:
- True histiocytic lymphoma is a rare malignancy characterized by proliferation of malignant histiocytes.
- Cutaneous involvement can occur but is uncommon, presenting diagnostic challenges.
Observation:
- A 73-year-old woman presented with multiple, fluctuating, and occasionally regressing cutaneous nodules.
- Dermal infiltration by tumor cells was observed, initially appearing histiocytic via light microscopy and marker studies.
Findings:
- Electron microscopy confirmed the histiocytic nature of the infiltrating cells.
- Similar histiocytic cells were identified in a bone marrow biopsy specimen.
- A diagnosis of true histiocytic lymphoma was established.
Implications:
- This case highlights the diagnostic complexities in evaluating histiocyte proliferation disorders.
- Electron microscopy plays a vital role in confirming the diagnosis of true histiocytic lymphoma.
- Understanding the presentation of cutaneous histiocytic lymphoma is important for early detection and management.