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Alpha-mannosidosis. Report of a case with morphologic, cytologic and immunohistochemical considerations
B Krishnan1, D R Mody, I Ramzy
1Department of Pathology, Baylor College of Medicine, Houston, Texas 77030.
Acta Cytologica
|May 1, 1994
Abstract:
We report the histopathologic features of the knee bone and synovium and the cytologic features of the synovial fluid from a patient with alpha-mannosidosis. The synovium showed marked papillary hyperplasia with infiltration of foamy histiocytes containing periodic acid-Schiff-positive, diastase-resistant material. Severe degenerative changes were seen in the knee bone. The synovial fluid showed increased numbers of macrophages containing periodic acid-Schiff-positive, diastase-resistant material. The differential diagnostic considerations in the synovial fluid are also discussed.