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Effect of high-dose steroid therapy on T-cell subpopulations. A longitudinal study in MS patients

P Gallo1, M Chiusole, M Sanzari

  • 1Institute of Neurology, Second Neurologic Clinic, University of Padua, School of Medicine, Italy.

Acta Neurologica Scandinavica
|February 1, 1994
PubMed

Lymphocyte subpopulations, T cell activation antigens, and serum levels of interleukin 2 (IL-2) and soluble IL-2 receptor (sIL2R), were studied in relapsing-remitting MS (RR-MS) patients before and after high-dose steroid therapy. Prior to therapy, a minority of patients showed increased HLA-DR antigen expression, and an increased number of CD16+ and CD19+ cells. Steroid treatment induced a significant increase in HLA-DR and CD19 expression, a significant reduction in CD16+, CD57+, and CD8+ CD57+ cells, and a slight, non-significant, decrease in IL-2 and sIL-2R levels and CD25 expression on CD4+ T lymphocytes.

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