Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glucose kinetics during exercise in trained men

M Hargreaves1, J Proietto

  • 1Department of Physiology, University of Melbourne, Parkville, Australia.

Acta Physiologica Scandinavica
|February 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterization of expiration air jets and droplet size distributions immediately at the mouth opening.

Journal of aerosol science·2020
Same author

Body mass index and health-related quality of life.

Obesity science & practice·2018
Same author

Combining biological and psychosocial baseline variables did not improve prediction of outcome of a very-low-energy diet in a clinic referral population.

Clinical obesity·2017
Same author

Effects of Reduced Training on Muscular Power in Swimmers.

The Physician and sportsmedicine·2016
Same author

Oral health and risk of colorectal cancer: results from three cohort studies and a meta-analysis.

Annals of oncology : official journal of the European Society for Medical Oncology·2016
Same author

Review of 3-year outcomes of a very-low-energy diet-based outpatient obesity treatment programme.

Clinical obesity·2016

During intense exercise, the body's glucose production doesn't always match glucose use by muscles. Beta-blockers like timolol impair glucose regulation and exercise performance in trained men.

Area of Science:

  • Exercise Physiology
  • Metabolic Regulation
  • Endocrinology

Background:

  • Maintaining blood glucose homeostasis is crucial during physical activity.
  • Hepatic glucose output and peripheral glucose uptake are key regulators of blood glucose during exercise.

Purpose of the Study:

  • To investigate the relationship between hepatic glucose production and peripheral glucose uptake during prolonged exercise in trained men.
  • To examine the role of beta-adrenergic signaling in glucose regulation and exercise capacity.

Main Methods:

  • Utilized a primed, continuous intravenous infusion of D-[3-3H]glucose to measure rates of appearance (Ra) and disappearance (Rd) of glucose.
  • Administered a non-selective beta-adrenergic antagonist (timolol) or placebo to assess its effects on glucose metabolism and exercise performance.

Related Experiment Videos

Main Results:

  • During exercise at 75% VO2max, hepatic glucose output (Ra) initially exceeded glucose uptake (Rd), with Ra peaking around 15 minutes.
  • Glucose uptake (Rd) continued to rise, reaching its maximum at the end of exercise.
  • Timolol administration significantly impaired exercise capacity and abolished the exercise-induced rise in blood glucose.

Conclusions:

  • Hepatic glucose output is not consistently matched to peripheral glucose uptake during high-intensity exercise in trained individuals.
  • Beta-adrenergic signaling plays a vital role in maintaining glucose homeostasis and enabling sustained exercise performance.