Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Development of an immune system

J J Marchalonis1, S F Schluter

  • 1Department of Microbiology and Immunology, University of Arizona, College of Medicine, Tucson 85724.

Annals of the New York Academy of Sciences
|April 15, 1994
PubMed
Summary

The immune system uses specific defense mechanisms involving T and B lymphocytes. While key immune molecules evolved early, genetic diversity mechanisms in antibodies differ across vertebrates, with clonal selection being universal.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Probing the boundaries of the extended immunoglobulin family of recognition molecules: jumping domains, convergence and minigenes.

Immunology today·2014
Same author

Further comments on the molecular members of extended immunoglobulin family.

Immunology today·2014
Same author

The T-cell antigen receptor: the minimal hypothesis revisited.

Immunology today·2014
Same author

Immunomodulation by immunopeptides and autoantibodies in aging, autoimmunity, and infection.

Annals of the New York Academy of Sciences·2006
Same author

A recognition of Joseph R. Goodman's scientific contributions.

Cellular and molecular biology (Noisy-le-Grand, France)·2005
Same author

Natural autoantibodies to TCR public idiotopes: potential roles in immunomodulation.

Cellular and molecular biology (Noisy-le-Grand, France)·2003

Area of Science:

  • Immunology
  • Evolutionary Biology
  • Comparative Genomics

Background:

  • The immune response involves cellular and humoral defense mechanisms specific to an antigen.
  • Immune memory and tolerance demonstrate the cognitive nature of the immune system.
  • T and B lymphocytes are central to antigen recognition in higher vertebrates, supported by accessory cells and cytokines.

Purpose of the Study:

  • To explore the evolutionary origins and diversity of immune system components.
  • To investigate the phylogenetic emergence of immune regulatory molecules.
  • To compare genetic mechanisms of antibody diversity in mammals and primitive vertebrates.

Main Methods:

  • Phylogenetic analysis of immune system genes.
  • Comparative genomics of antibody heavy and light chains.
  • Review of existing literature on immune responses across deuterostomes and protostomes.

Main Results:

  • Molecules for cell adhesion and regulation predate the divergence of protostomes and deuterostomes.
  • Genetic mechanisms for antibody diversity likely differ between mammals and primitive vertebrates like elasmobranchs.
  • Clonal selection of lymphocyte antigen receptors is likely a universal vertebrate trait.

Conclusions:

  • Immune system evolution involves ancient regulatory molecules and later diversification mechanisms.
  • Mammalian immune models may not be universally applicable to all vertebrates or invertebrates.
  • Understanding immune diversity across species is crucial for a comprehensive view of immunology.

Related Experiment Videos