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Related Experiment Video

Updated: Jun 30, 2026

Primary Culture of Human Vestibular Schwannomas
10:50

Primary Culture of Human Vestibular Schwannomas

Published on: July 20, 2014

Malignant acoustic schwannoma

R E Mrak1, S Flanigan, C L Collins

  • 1Department of Pathology, Department of Veterans Affairs Medical Center, Little Rock, AR.

Archives of Pathology & Laboratory Medicine
|May 1, 1994
PubMed
Summary
This summary is machine-generated.

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This study reports a rare, aggressive pleomorphic Schwann cell tumor in a 40-year-old man. Despite resection and radiotherapy, the tumor demonstrated rapid regrowth and metastasis, highlighting its malignant potential.

Area of Science:

  • Neurosurgery
  • Oncology
  • Pathology

Background:

  • Schwann cell tumors typically arise in the peripheral nervous system.
  • Pleomorphic variants are rare and can exhibit aggressive behavior.

Observation:

  • A 40-year-old man presented with a cerebellopontine angle tumor without neurofibromatosis stigmata.
  • Histopathology revealed multinucleated giant cells, pleomorphism, and S100 protein immunoreactivity.
  • Tumor recurred rapidly after initial resection, showing similar histology but altered flow cytometry findings.

Findings:

  • The tumor exhibited extreme pleomorphism, tripolar mitoses, and aneuploidy, suggesting malignancy.
  • Post-resection, flow cytometry revealed a double aneuploid population with increased tetraploid S-phase nuclei.

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Last Updated: Jun 30, 2026

Primary Culture of Human Vestibular Schwannomas
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Published on: July 20, 2014

A Unified Methodological Framework for Vestibular Schwannoma Research
08:43

A Unified Methodological Framework for Vestibular Schwannoma Research

Published on: June 20, 2017

Surgical Treatment of an Endolymphatic Sac Tumor
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Published on: May 26, 2023

  • Radiotherapy halted initial regrowth but did not prevent subsequent metastatic spread.

    • Implications:

    • This case underscores the potential for aggressive behavior and metastasis in pleomorphic Schwann cell tumors.
    • Advanced flow cytometry aids in assessing tumor ploidy and malignancy.
    • Multimodal treatment strategies may be necessary for managing such rare, aggressive neoplasms.