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Multi-infarct dementia in Down's syndrome

R A Collacott1, S A Cooper, I A Ismail

  • 1Frith Hospital, Leicester, England.

Journal of Intellectual Disability Research : JIDR
|April 1, 1994
PubMed
Summary
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This study reports a case of multi-infarct dementia and Alzheimer's disease in a woman with Down's syndrome. Such co-occurring conditions may be under-recognized in this population.

Area of Science:

  • Neurology
  • Genetics
  • Gerontology

Background:

  • Down's syndrome is frequently associated with Alzheimer's disease pathology.
  • The contribution of cerebrovascular disease to dementia in Down's syndrome is less understood.

Observation:

  • A 55-year-old woman with Down's syndrome presented with a dementing illness.
  • Clinical and pathological evidence suggested both Alzheimer's disease and multi-infarct dementia.

Findings:

  • The case highlights the potential for co-occurrence of Alzheimer's disease and multi-infarct dementia in individuals with Down's syndrome.
  • Cerebrovascular disease may significantly contribute to cognitive decline in this demographic.

Implications:

  • These findings suggest that multi-infarct dementia may be under-diagnosed in individuals with Down's syndrome.

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  • Further research is warranted to explore the prevalence and impact of cerebrovascular disease in Down's syndrome-associated dementia.