Related Experiment Videos
Intraosseous adenosine. As effective as peripheral or central venous administration?
S J Getschman1, A M Dietrich, W H Franklin
1Division of Clinical Pharmacology/Toxicology, Ohio State University, Children's Hospital, Columbus.
Archives of Pediatrics & Adolescent Medicine
|June 1, 1994
Summary
Intraosseous adenosine administration is effective for inducing atrioventricular block. Dosing for the intraosseous route is comparable to central and peripheral venous routes in piglets.
Area of Science:
- Pharmacology
- Emergency Medicine
- Veterinary Medicine
Background:
- Adenosine is a critical drug for managing supraventricular tachycardias.
- Established routes for adenosine administration include peripheral and central venous access.
- Intraosseous (IO) access provides a reliable alternative route for drug delivery in emergency situations.
Purpose of the Study:
- To evaluate the efficacy of intraosseous adenosine administration.
- To establish therapeutic dosage criteria for the intraosseous route compared to venous routes.
Main Methods:
- A randomized, unblinded, cross-over, within-animal control study was conducted.
- Thirty newly weaned piglets underwent transesophageal or transvenous pacing.
- The minimum effective dose of adenosine to induce atrioventricular block was determined for peripheral venous, central venous, and intraosseous routes.
Main Results:
- No significant differences in baseline heart rate or Wenckebach thresholds were observed between routes.
- The median effective intraosseous dose of adenosine was 127 micrograms/kg.
- The intraosseous dose was not statistically different from central or peripheral venous doses, though peripheral venous doses were significantly higher than central venous doses.
Conclusions:
- Intraosseous administration of adenosine is effective in achieving atrioventricular block.
- The intraosseous route offers a viable alternative for adenosine delivery, with dosage requirements comparable to central and peripheral venous routes.