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Cardioreparation and the concept of modulating cardiovascular structure and function
K T Weber1, C G Brilla, J G Cleland
1Department of Internal Medicine, University of Missouri-Columbia.
Insights
Hypertension and cardiovascular disease are global health issues. Therapies can restore structural and functional abnormalities in the heart and vasculature caused by conditions like left ventricular hypertrophy.
Area of Science:
- Cardiovascular Medicine
- Pathophysiology
- Medical Research
Background:
- Hypertension and atherosclerotic cardiovascular disease are significant global health challenges.
- Left ventricular hypertrophy is a primary risk factor for adverse cardiovascular events.
- The renin-angiotensin-aldosterone system plays a key role in modulating cell growth and cardiovascular structure.
Purpose of the Study:
- To review experimental and clinical trials investigating the concept of 'reparation' in cardiovascular disease.
- To emphasize the role of structural abnormalities in the heart and vasculature in disease pathophysiology.
- To explore therapeutic strategies aimed at restoring normal structure and function to the remodelled cardiovascular system.
Main Methods:
- Review of experimental and clinical trials.
- Analysis of the role of growth factors, regulatory peptides, and hormones in cardiovascular remodelling.
- Examination of the relationship between structural abnormalities and impaired cardiac and vascular function.
Main Results:
- Structural abnormalities in the heart and vasculature are central to cardiovascular disease.
- The concept of reparation suggests that therapeutic interventions can reverse structural damage.
- Therapy can potentially restore normal structure and function to the affected cardiovascular system.
Conclusions:
- Abnormalities in tissue structure are fundamental to the pathophysiology of cardiovascular diseases.
- Therapeutic interventions hold promise for restoring normal structure and function to the remodelled heart and vasculature.
- Further research and clinical trials are warranted to validate reparative strategies for cardiovascular conditions.
Abstract:
Hypertension and atherosclerotic cardiovascular disease represent major global health problems. Practising physicians are challenged daily by patients suffering adverse cardiovascular events, such as myocardial infarction, stroke, heart failure and sudden cardiac death. Major risk factors have been identified of which the most important is left ventricular hypertrophy. In recent years, growth factors, regulatory peptides and effector hormones of the renin-angiotensin-aldosterone system have been identified as important modulators of cell growth and behaviour. It therefore follows that a major emphasis has been placed on the importance of abnormalities in organ structure as the primary basis for impaired function of the heart and vasculature, including large and medium sized arteries and resistance vessels, or arterioles. The concept of reparation recognizes the importance of abnormalities in tissue structure to the functional basis of disease. It suggests that the structurally remodelled heart and vasculature can be restored to, or toward, normal structure and function by suitable therapy. Experimental and clinical trials which address this premise are reviewed herein.