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Fetoscopy-guided fetal endoscopy in a sheep model

F I Luks¹, J A Deprest, K Vandenberghe

¹Centre of Surgical Technologies, University Hospital Gasthuisberg, Catholic University of Leuven, Belgium.

Journal of the American College of Surgeons

|June 1, 1994

Summary

Fetal endoscopy offers a minimally invasive approach for examining fetal anatomy. This new technique shows promise as a research tool for studying fetal physiology in situ.

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Area of Science:

Veterinary Medicine
Surgical Innovation
Fetal Medicine

Background:

Open fetal surgery presents significant risks.
Minimally invasive techniques are sought to reduce fetal and maternal morbidity.

Purpose of the Study:

To evaluate the feasibility and safety of intrauterine fetal endoscopy in lambs.
To explore the potential of endoscopy for examining fetal anatomy and physiology.

Main Methods:

Six 95-day-old fetal lambs underwent intrauterine endoscopy with amnioinfusion.
Specialized balloon-tipped cannulas and rigid/flexible endoscopes were utilized.
Fetal vital signs (oxygen saturation, heart rate, temperature) were monitored.

Main Results:

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The respiratory and upper gastrointestinal tracts were successfully visualized.
No mucosal trauma or other adverse effects were observed.
All fetal lambs survived the endoscopic procedure without complications.

Conclusions:

Intrauterine fetal endoscopy is a feasible and safe technique in a lamb model.
While clinical applications require further demonstration, fetal endoscopy shows potential as a research tool for in situ fetal physiological studies.