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Updated: Aug 24, 2026

Measurement of Insulin- and Contraction-Stimulated Glucose Uptake in Isolated and Incubated Mature Skeletal Muscle from Mice
Published on: May 16, 2021
Differing patterns of carbohydrate metabolism in liver and muscle
Abstract:
The effect of a period of starvation followed by refeeding on skeletal muscle glycogen was investigated by the use of double-labelled radioactive glucose precursors in rats. Skeletal muscle glycogen, which is not depleted to anything like the extent of liver glycogen, shows a remarkable stability with respect to its overall molecular size distribution during starvation and subsequent refeeding. The experiments also indicate that there is a control mechanism in muscle tissue enabling the synthesis of lysosomal glycogen to be switched off during the initial part of the refeeding process. The results emphasise the inadequacy of the Cori cycle and a modified version is proposed.
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