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A chemoenzymatic synthesis of D-myo-inositol 1,4,5-trisphosphate
1Department of Applied Chemistry, Faculty of Engineering, Ehime University, Matsuyama, Japan.
Carbohydrate Research
|March 18, 1994
Abstract:
Enzyme-catalyzed esterification of racemic 2,3-O-cyclohexylidene-myo-inositol (DL-1) proceeded exclusively in 1,4-dioxane to give optically pure L-1-O-acetyl-2,3-O-cyclohexylidene-myo-inositol (L-2) and D-2,3-O-cyclohexylidene-myo-inositol (D-1). A new practical route has been developed for the synthesis of D-myo-inositol 1,4,5-trisphosphate starting from D-1 via selective acylation of the 6-hydroxyl group.