Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Crystals and arthritis

D J McCarty1

  • 1Department of Medicine, MCW Arthritis Institute Medical College of Wisconsin, Milwaukee.

Disease-A-Month : DM
|June 1, 1994
PubMed
Summary
This summary is machine-generated.

Crystal aggregates like monosodium urate and calcium pyrophosphate dihydrate are linked to gout and pseudogout. These crystals trigger inflammation and joint damage, necessitating new therapeutic strategies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Health characteristics of inland waterway merchant marine captains and pilots.

Occupational medicine (Oxford, England)·2012
Same author

Diagnostic thresholds for diabetes: the association of retinopathy and albuminuria with glycaemia.

Diabetes research and clinical practice·2006
Same author

Epidemiology of systemic lupus erythematosus in rural Wisconsin.

Lupus·2005
Same author

Birth weight and systemic lupus erythematosus.

Lupus·2005
Same author

Trends in health service delivery for cataract surgery at a large Australian ophthalmic hospital.

Clinical & experimental ophthalmology·2001
Same author

Controlled study of the use of autologous serum in dry eye patients.

Cornea·2001
Same journal

GLP-1 agonist and neuroprotection in Stroke and Parkinson's disease: A systematic review.

Disease-a-month : DM·2026
Same journal

GLP-1 receptor agonists for weight management and potential thromboembolic risk reduction in high risk population with cancer, diabetes, cardiovascular disease: A systematic review.

Disease-a-month : DM·2026
Same journal

Insulin autoimmune syndrome (Hirata Disease): An updated review of epidemiology, pathophysiology, clinical features, diagnosis, and management.

Disease-a-month : DM·2026
Same journal

Primary ciliary dyskinesia in pediatric persons: A microscopic movement malady.

Disease-a-month : DM·2026
Same journal

Approved weight loss drugs for obesity with a thorough emphasis on GLP-1 agonist medications: A systematic review.

Disease-a-month : DM·2026
See all related articles

Area of Science:

  • Rheumatology
  • Crystal-Induced Arthropathies
  • Biochemistry

Background:

  • Monosodium urate (MSU), calcium pyrophosphate dihydrate (CPPD), and basic calcium phosphate (BCP) crystals are implicated in gout, pseudogout, and degenerative joint diseases.
  • Hyperuricemia and elevated synovial fluid inorganic pyrophosphate are inconsistent markers for gout and pseudogout, respectively.
  • These crystal types are increasingly prevalent in an aging population.

Purpose of the Study:

  • To review the association of MSU, CPPD, and BCP crystals with joint diseases.
  • To elucidate the inflammatory and destructive mechanisms induced by these crystals.
  • To discuss potential therapeutic avenues based on crystal biology.

Main Methods:

  • Literature review of crystal-induced arthropathies.

Related Experiment Videos

  • Analysis of the biological effects of MSU, CPPD, and BCP crystals on joint tissues.
  • Examination of inflammatory pathways including phagocytosis, neutral protease synthesis, and arachidonic acid metabolism.

    • Main Results:

    • MSU, CPPD, and BCP crystals induce acute inflammation via neutrophilic leukocyte phagocytosis.
    • These crystals stimulate neutral protease and arachidonic acid metabolism in synoviocytes and macrophages in a dose-dependent manner.
    • Calcium-containing crystals act as potent mitogens, contributing to joint tissue damage.

    Conclusions:

    • Crystal aggregates are key players in gout, pseudogout, osteoarthritis, and Milwaukee Shoulder/Knee Syndrome.
    • Understanding the biological effects of these crystals is crucial for developing targeted therapies.
    • New drug development targeting crystal-induced inflammation and damage holds therapeutic promise.