Lilly Lecture 1993. Glycation and diabetic complications

Neuronal overexpression of Glo1 or amygdalar microinjection of methylglyoxal is sufficient to regulate anxiety-like behavior in mice.

Behavioural brain research·2015

Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology.

Diabetologia·2011

Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress.

Diabetologia·2010

Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes.

Diabetologia·2008

Effect of R-(+)-alpha-lipoic acid on experimental diabetic retinopathy.

Diabetologia·2006

Inositols prevent and reverse endothelial dysfunction in diabetic rat and rabbit vasculature metabolically and by scavenging superoxide.

Proceedings of the National Academy of Sciences of the United States of America·2005

HGF Endogenously Produced by Pancreatic Pericytes Regulates β-Cell Function.

Diabetes·2026

Comparing the Independent Effects of Weight Loss or Exercise Training on Skeletal Muscle Lipid Localization and Insulin Sensitivity in Humans.

Diabetes·2026

Baseline Serum Metabolites as Predictors of Teplizumab Response in Individuals With Type 1 Diabetes.

Diabetes·2026

Organelle-Specific Lipid Profiles Underlie Metabolic Health in a Nutrition-Dependent Manner.

Diabetes·2026

Body Composition-Driven Phenotyping Reveals Obesity and Cardiometabolic Heterogeneity in Children Using a Tree-Like Representation.

Diabetes·2026

Human Loss-of-Function ZNRF3 Mutation Impairs Adipose Thermogenesis and Drives Subcutaneous Fat Expansion.

Diabetes·2026

Conditioned Media-Derived Tumor Extracellular Vesicles: Bridging Molecular Insights and Therapeutic Applications in Oncology.

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology·2026

The Silent Intruder: A Case Report of an Incidentally Discovered Solitary Fibrous Tumor of the Lung.

Cureus·2026

Development and progression of hepatic steatosis during long-term glucocorticoid therapy in autoimmune hepatitis: multimodal evidence from biopsy, CAP, and ultrasound.

Frontiers in medicine·2026

An oral fentanyl self-administration model reveals dissociable escalation and relapse phenotypes in outbred vs inbred mice.

bioRxiv : the preprint server for biology·2026

Sex-dependent chronic neurological dysfunction following isoflurane anesthesia and surgery is associated with circulating extracellular vesicle-mediated neuroinflammatory signaling.

bioRxiv : the preprint server for biology·2026

Actively cycling cells in uninjured connective tissue are not a prerequisite for appendage regeneration.

bioRxiv : the preprint server for biology·2026

Related Experiment Videos

Lilly Lecture 1993. Glycation and diabetic complications

Related Concept Videos

Neuronal overexpression of Glo1 or amygdalar microinjection of methylglyoxal is sufficient to regulate anxiety-like behavior in mice.

Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology.

Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress.

Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes.

Effect of R-(+)-alpha-lipoic acid on experimental diabetic retinopathy.

Inositols prevent and reverse endothelial dysfunction in diabetic rat and rabbit vasculature metabolically and by scavenging superoxide.

HGF Endogenously Produced by Pancreatic Pericytes Regulates β-Cell Function.

Comparing the Independent Effects of Weight Loss or Exercise Training on Skeletal Muscle Lipid Localization and Insulin Sensitivity in Humans.

Baseline Serum Metabolites as Predictors of Teplizumab Response in Individuals With Type 1 Diabetes.

Organelle-Specific Lipid Profiles Underlie Metabolic Health in a Nutrition-Dependent Manner.

Body Composition-Driven Phenotyping Reveals Obesity and Cardiometabolic Heterogeneity in Children Using a Tree-Like Representation.

Human Loss-of-Function ZNRF3 Mutation Impairs Adipose Thermogenesis and Drives Subcutaneous Fat Expansion.

Conditioned Media-Derived Tumor Extracellular Vesicles: Bridging Molecular Insights and Therapeutic Applications in Oncology.

The Silent Intruder: A Case Report of an Incidentally Discovered Solitary Fibrous Tumor of the Lung.

Development and progression of hepatic steatosis during long-term glucocorticoid therapy in autoimmune hepatitis: multimodal evidence from biopsy, CAP, and ultrasound.

An oral fentanyl self-administration model reveals dissociable escalation and relapse phenotypes in outbred vs inbred mice.

Sex-dependent chronic neurological dysfunction following isoflurane anesthesia and surgery is associated with circulating extracellular vesicle-mediated neuroinflammatory signaling.

Actively cycling cells in uninjured connective tissue are not a prerequisite for appendage regeneration.

Related Experiment Videos

Lilly Lecture 1993. Glycation and diabetic complications

Related Concept Videos

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