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Related Concept Videos

  • Physical Sciences
  • Condensed Matter Physics
  • Surface Properties Of Condensed Matter
  • Satiety Effects Of Cholecystokinin In Humans
  • Physical Sciences
  • Condensed Matter Physics
  • Surface Properties Of Condensed Matter
  • Satiety Effects Of Cholecystokinin In Humans

    • Related Experiment Videos

    Satiety effects of cholecystokinin in humans

    R J Lieverse1, J B Jansen, A M Masclee

    • 1Department of Gastroenterology and Hepatology, University Hospital of Leiden, The Netherlands.

    Gastroenterology
    |June 1, 1994

    View abstract on PubMed

    Summary
    This summary is machine-generated.

    Cholecystokinin (CCK) significantly increases feelings of fullness and reduces hunger at physiological levels in humans. This peptide hormone plays a key role in appetite regulation and satiety, impacting both lean and obese individuals.

    Related Experiment Videos

    Area of Science:

    • Gastroenterology
    • Endocrinology
    • Neuroscience

    Background:

    • Cholecystokinin (CCK) is known to inhibit gastric emptying and influence satiety in various species.
    • The precise effects of physiological CCK doses on human satiety remain incompletely understood.
    • Investigating CCK-33's role in appetite regulation in both lean and obese individuals is crucial.

    Purpose of the Study:

    • To determine the satiety effects of cholecystokinin-33 (CCK-33) at physiological plasma concentrations in humans.
    • To compare these effects between lean and obese subjects.

    Main Methods:

    • Intravenous infusion of CCK-33 to 32 healthy participants (14 obese, 18 lean).
    • Doses were selected to achieve physiological plasma CCK levels.
    • Subjective measures of hunger, desire to eat, fullness, and feeding intentions were assessed using visual analogue scales.

    Main Results:

    • CCK infusions significantly reduced hunger, desire to eat, and prospective feeding intentions (P < 0.05).
    • Fullness showed a trend towards increase (P = 0.054).
    • Minor differences between lean and obese groups were noted, primarily concerning fullness and feeding intentions during saline infusion.

    Conclusions:

    • CCK infusion at physiological levels demonstrably enhances satiety in humans.
    • CCK is a significant regulator of appetite and food intake in humans.