Isolation and characterization of adenovirus-associated VA RNAs of human adenovirus type 7
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1Wyeth-Ayerst Research, Biotechnology and Microbiology Division, Philadelphia, PA 19101.
Gene
|May 16, 1994
Abstract:
Two genes for virus-associated VA RNAs in the human adenovirus type 7 (Ad7) genome are compared to Ad2, Ad4, Ad5, simian VA RNAs, and pol III transcripts of Epstein-Barr virus. The newly identified VA RNA-encoding genes of Ad7 contain two relatively conserved intragenic promoter (elements A and B), the double-stranded RNA-dependent protein kinase (PK) active site-binding domain and transcriptional terminators. The conserved features extend to the VA RNA genes of simian and avian origin.