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Related Experiment Videos

Amlodipine-induced gingival overgrowth

R A Seymour1, J S Ellis, J M Thomason

  • 1Department of Restorative Dentistry, University of Newcastle-upon-Tyne, UK.

Journal of Clinical Periodontology
|April 1, 1994
PubMed
Summary

Amlodipine, a common drug for hypertension and angina, may cause gingival overgrowth. This side effect, observed in patients using the drug long-term, was linked to amlodipine found in crevicular fluid.

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Area of Science:

  • Pharmacology
  • Periodontology
  • Drug-induced side effects

Background:

  • Amlodipine is a widely prescribed calcium channel blocker for cardiovascular conditions.
  • Gingival overgrowth is a known, though uncommon, side effect of certain medications.

Purpose of the Study:

  • To report and investigate cases of gingival overgrowth associated with amlodipine use.
  • To explore the potential role of amlodipine sequestration in gingival crevicular fluid.

Main Methods:

  • Case series reporting three adult patients with gingival overgrowth.
  • Clinical observation of gingival changes and patient history.
  • Analysis of amlodipine presence in crevicular fluid.

Main Results:

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  • Three adult patients developed gingival overgrowth within three months of starting amlodipine.
  • Pre-existing periodontal disease appeared to exacerbate the gingival changes.
  • Amlodipine was detected in the crevicular fluid of all affected patients.

Conclusions:

  • Chronic amlodipine use may lead to gingival overgrowth, particularly in patients with compromised periodontal health.
  • The presence of amlodipine in crevicular fluid suggests a localized mechanism.
  • Further research is needed to clarify the exact role of amlodipine in the pathogenesis of drug-induced gingival overgrowth.