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Related Experiment Videos

Variance component modeling of attachment level measurements

J C Gunsolley1, D A Williams, H A Schenkein

  • 1Clinical Research Center for Periodontal Diseases, Virginia Commonwealth University, Richmond.

Journal of Clinical Periodontology
|April 1, 1994
PubMed
Summary

Attachment-level measurements in periodontitis studies are influenced by variability within subjects and teeth. Accounting for this tooth and subject variance is crucial for accurate hypothesis testing in periodontitis research.

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Area of Science:

  • Periodontology
  • Biostatistics

Background:

  • Attachment-level measurements are critical for assessing periodontal disease progression.
  • Understanding variability in these measurements is essential for robust clinical trial design and data analysis.

Purpose of the Study:

  • To investigate the impact of within-subject and within-tooth variability on hypothesis testing for attachment-level measurements.
  • To determine the distribution of variance at site, tooth, and subject levels in different periodontitis populations.

Main Methods:

  • Collected full-mouth attachment-level measurements from 4 sites per tooth.
  • Included subjects with early-onset localized and generalized periodontitis, and adult periodontitis.
  • Utilized variance component models with iterative generalized least squares to estimate variance distribution.

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Main Results:

  • A significant percentage of variance in attachment-level measurements was found at the tooth and subject levels.
  • Ignoring tooth or subject variance can lead to an underestimation of Type I error rates in hypothesis testing.

Conclusions:

  • Both subject and tooth levels must be incorporated into models for attachment-level measurements.
  • For studies with limited sampling, selecting samples from different teeth can simplify data analysis.