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Related Experiment Videos

Benign and secondary progressive multiple sclerosis: a preliminary quantitative MRI study

M Filippi1, G J Barker, M A Horsfield

  • 1Institute of Neurology, Queen Square, London, UK.

Journal of Neurology
|February 1, 1994
PubMed
Summary

Quantitative MRI reveals differences in chronic brain lesions between benign and secondary progressive multiple sclerosis (MS). Small lesions in benign MS show higher T2 values, while secondary progressive MS may have greater axonal loss in larger lesions.

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Area of Science:

  • Neurology
  • Radiology
  • Neuroimaging

Background:

  • Multiple Sclerosis (MS) is a chronic neurological disease characterized by demyelination and axonal damage.
  • Understanding the mechanisms of disability progression in MS is crucial for effective treatment strategies.
  • Quantitative magnetic resonance imaging (MRI) offers insights into lesion characteristics and their relationship to disease evolution.

Purpose of the Study:

  • To compare T2 values and decay characteristics of chronic brain lesions in benign MS versus secondary progressive MS.
  • To assess T2 values of normal-appearing white matter (NAWM) in both MS subtypes.
  • To evaluate brain lesion volumes and their correlation with disability development in MS.

Main Methods:

  • Quantitative MRI techniques were employed to measure T2 values and lesion volumes.

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  • A cohort of 11 patients with clinically definite MS (5 benign, 6 secondary progressive) was studied.
  • Fifty-two chronic lesions were identified and analyzed, alongside NAWM, using established MRI protocols.

    • Main Results:

    • Small lesions exhibited higher mean T2 values in benign MS, potentially due to partial volume effects.
    • Biexponential T2 relaxation, indicative of axonal loss, was observed more frequently in large lesions of secondary progressive MS patients.
    • While not statistically significant, secondary progressive MS patients showed a trend towards higher total and infratentorial lesion loads.

    Conclusions:

    • Preliminary findings suggest that lesion characteristics, including size, location, and pathological nature (e.g., axonal loss), may influence disease progression patterns in MS.
    • Quantitative MRI parameters like T2 relaxation times can potentially differentiate between MS subtypes and predict disability.
    • Further research is warranted to establish the definitive role of these MRI metrics in understanding MS pathogenesis and evolution.