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[Thyrotropin receptor is expressed in non-thyroid tissues]

T Endo1, T Onaya

  • 1Third Department of Internal Medicine, University of Yamanashi Medical School.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|April 1, 1994
PubMed
Summary

Thyroid-stimulating hormone receptor (TSH-R) is expressed in non-thyroid tissues like adipose tissue. This finding expands our understanding of TSH-R distribution and function beyond the thyroid gland.

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Area of Science:

  • Endocrinology
  • Molecular Biology
  • Genetics

Context:

  • The thyroid-stimulating hormone receptor (TSH-R) is primarily known for its role in regulating thyroid function.
  • Previous research has focused on TSH-R expression within the thyroid gland.

Purpose:

  • To investigate the presence and expression of TSH-R in non-thyroidal tissues.
  • To characterize the molecular identity of TSH-R in rat retro-orbital and adipose tissues.

Summary:

  • TSH-R cDNA fragments were successfully amplified from rat retro-orbital and adipose tissues, as well as FRTL5 cells using PCR.
  • The nucleotide sequence of non-thyroidal TSH-R cDNA was found to be identical to that of thyroidal TSH-R.
  • Northern blot analysis revealed a high abundance of TSH-R mRNA in adipose tissue.
  • Antibody characterization confirmed the presence of TSH-R protein (100-104 kDa) in both adipose and retro-orbital tissues.

Impact:

  • Suggests a broader role for TSH-R beyond thyroid regulation.
  • Opens new avenues for research into TSH-R function in non-thyroidal tissues.
  • Potential implications for understanding and treating conditions involving non-thyroidal tissues.

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