Related Experiment Video
Updated: Aug 8, 2026

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins
Published on: March 22, 2012
[Domain structure and signal transduction mechanisms in the thyrotropin receptor]
1First Department of Internal Medicine, Nagasaki University School of Medicine.
Abstract:
The thyrotropin receptor is a single polypeptide (744 amino acids) consisting of two domains (N-terminal extracellular domain and C-terminal transmembrane/cytoplasmic region). The former (398 aa) contains six potential glycosylation sites, 11 cysteins and 9 leucine rich repeats and is very likely to be the major TSH binding site. On the other hand, the latter (346 aa) has a characteristic of G protein coupled receptors (seven transmembrane segments, 3 extracellular-and cyto-plasmic loops and a carboxyl terminal tail), contains potential phosphorylation sites (serine/threonine residues) for c-kinase and G-protein coupled receptor kinase and plays important roles in signal transduction and homologous desensitization. Experimentally-produced and naturally-occurring mutant receptors provide molecular mechanisms of receptor function.
Related Concept Videos
Cell-surface Signaling
Amplifying Signals via Enzymatic Cascade
Receptor Tyrosine Kinases
Signal Transduction: Overview
Typically, signal transduction involves three...
Transducer Mechanism: Enzyme-Linked Receptors
Major types that are helpful drug targets include:
Synthesis and Regulation of Thyroid Hormones
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...

